Orlando International Airport: The sensible choice for most flights, but only if you rent a car. Titusville is roughly 50–65 minutes northeast via FL-528 and FL-407; expect tolls plus fuel. A rideshare/private shuttle is usually about $80–140 one way and is poor value unless you will not leave downtown. There is no useful airport-to-Titusville public-transit transfer.
Melbourne Orlando International Airport: The closest commercial airport, about 45–55 minutes south by car. Rent at the airport; rideshare/private transfer is roughly $60–100 one way. It is especially practical for a Space Coast itinerary, but has far fewer flight choices than MCO.
Orlando Sanford International Airport: About 45–60 minutes west/northwest by car, generally via SR-46/I-95. Rent a car or budget roughly $55–90 for rideshare; there is no efficient rail or scheduled public-transport connection to Titusville.
Space Coast Regional Airport: Titusville’s airport is for general aviation only, with no scheduled commercial flights. It is close to town, but not an arrival option for ordinary airline travelers.
Orlando Amtrak station: There is no rail station in Titusville. If you arrive by Amtrak in Orlando, treat it as a car-rental or pre-booked-transfer arrival: roughly 55–75 minutes to Titusville and typically around $90–150 by rideshare, depending on time and demand. Do not plan on a seamless train-and-bus connection.
Titusville Greyhound/FlixBus stop: Useful only if the timetable happens to suit: intercity buses run along I-95 and can connect with Orlando and Florida’s east coast. The stop is not a substitute for a car once you arrive; book a rideshare or arrange pickup for lodging and attractions.